Dimethylformamide → 6-Bromo-2-chloroquinoxaline

HRID 1020733노트

반응식

HRID 1020733 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[CH:6]=[N:5]2.CN(C=O)C.O=P(Cl)(Cl)[Cl:20]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:20])[CH:6]=[N:5]2

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 126863946-Bromo-1,2-dihydroquinoxalin-2-one

생성물 1

HCID 126864086-Bromo-2-chloroquinoxaline

반응 조건

온도
50 °C

실험 절차

6-bromoquinoxalin-2(1H)-one (9.0 g, 40 mmol) was dissolved in POCl3 (50 mL) and DMF (2 mL) was added at RT. The mixture was heated at 50° C. for 2 hours. After completion of the reaction it was cooled to RT and was poured slowly into ice cold water. The mixture was stirred for 30 minutes and then filtered to afford crude product.

후처리

  1. customAfter completion of the reaction it
  2. temperaturewas cooled to RT
  3. additionwas poured slowly into ice cold water
  4. filtrationfiltered
  5. customto afford crude product

출처 및 근거

ORD 기록
ord-3e5ac592b50a4e9a9d396461501217df
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716473B2

반응 노트

불러오는 중…