Sodium Hydroxide → Sodium salt

HRID 1020782노트

반응식

HRID 1020782 반응식
[CH3:1][C:2]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([NH:14][C:15]2[C:16]([O:31][C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:37]=3[O:38][CH3:39])=[C:17]([O:27][CH2:28][CH2:29][OH:30])[N:18]=[C:19]([C:21]3[N:22]=[CH:23][CH:24]=[CH:25][N:26]=3)[N:20]=2)(=[O:13])=[O:12])=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[OH-].[Na+:41]>O>[CH3:4][C:2]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([N-:14][C:15]2[C:16]([O:31][C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:37]=3[O:38][CH3:39])=[C:17]([O:27][CH2:28][CH2:29][OH:30])[N:18]=[C:19]([C:21]3[N:26]=[CH:25][CH:24]=[CH:23][N:22]=3)[N:20]=2)(=[O:12])=[O:13])=[CH:7][CH:6]=1)([CH3:1])[CH3:3].[Na+:41]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 104865Bosentan

생성물 1

HCID 44387533Sodium salt

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

A mixture of bosentan (2 g) in de-ionized water (24 mL) was heated to 50° C. followed by the addition of sodium hydroxide (0.175 g). The reaction mixture was stirred for 3.5 hours at the same temperature and the solid was filtered, washed with de-ionized water (6 mL) and dried under hot air oven at 55° C. to 60° C. to obtain the title compound.

후처리

  1. filtrationthe solid was filtered
  2. washwashed with de-ionized water (6 mL)
  3. customdried under hot air oven at 55° C. to 60° C.

출처 및 근거

ORD 기록
ord-b32c21d11b5a40998f4aca54c233edf9
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716477B2

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