Methanol → 4-Methoxy-1H-pyrrolo[2,3-b]pyridine

HRID 1020905노트

반응식

HRID 1020905 반응식
[OH-:1].[Na+].Cl[C:4]1[CH:12]=[CH:11][N:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2.[CH3:13]O>>[CH3:13][O:1][C:4]1[CH:12]=[CH:11][N:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2

참가 물질

4

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridine

실험 절차

A solution of sodium hydroxide (11 g) in methanol (250 mL) was stirred with 4-chloro-1H-pyrrolo[2,3-b]pyridine (step 2)(12.2 g, 80 mmol) at 140° C. in a sealed reactor for 16 hr. After being cooled to ambient temperature the mixture was concentrated and residue was slurred in water (100 mL) for one hour. The solid was collected by suction filtration and washed to neutrality with water. After being dried to constant weight, 6.5 g of 4-methoxy-7-azaindole was obtained as a tan solid; MS (m/z) 149 (M+H).

후처리

  1. concentrationwas concentrated
  2. filtrationThe solid was collected by suction filtration
  3. washwashed
  4. customAfter being dried to constant weight

출처 및 근거

ORD 기록
ord-6d758ae00c394184803892307e5fcb4f
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716493B2

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