Sodium Hydroxide → HCID 67273211, 화합물

HRID 1020918노트

반응식

HRID 1020918 반응식
C1(S([N:10]2[C:18]3[C:13](=[C:14]([O:21][CH3:22])[C:15]([O:19][CH3:20])=[CH:16][CH:17]=3)[CH:12]=[C:11]2[C:23]2[CH2:27][CH2:26][CH2:25][CH:24]=2)(=O)=O)C=CC=CC=1.[OH-].[Na+]>CCO>[C:23]1([C:11]2[NH:10][C:18]3[C:13]([CH:12]=2)=[C:14]([O:21][CH3:22])[C:15]([O:19][CH3:20])=[CH:16][CH:17]=3)[CH2:27][CH2:26][CH2:25][CH:24]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67273154HCID 67273154, 화합물

생성물 1

HCID 67273211HCID 67273211, 화합물수율 97.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 291 mg (0.76 mmol) of the phenylsulfonamide intermediate from step 3 in 50 mL EtOH was added 5 mL 10% NaOH solution. The reaction was heated to reflux overnight and then concentrated. The residue was dissolved in EtOAc, washed with 2N Na2CO3 solution, H2O, aqueous NaCl solution, dried (MgSO4), and concentrated under vacuum to yield 180 mg of 2-cyclopent-1-enyl-4,5-dimethoxy-1H-indole (97%).

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. concentrationconcentrated
  4. dissolutionThe residue was dissolved in EtOAc
  5. washwashed with 2N Na2CO3 solution, H2O, aqueous NaCl solution
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-db94dbbd12de40a491c48efc13c09c28
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716493B2

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