Water → 4-(chloromethyl)-7-hydroxy-8-methyl-2H-chromen-2-one
반응식
[CH3:1][C:2]1[C:8]([OH:9])=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4].[Cl:10][CH2:11][C:12](=O)[CH2:13][C:14](OCC)=[O:15].O>CS(O)(=O)=O>[Cl:10][CH2:11][C:12]1[C:5]2[C:3](=[C:2]([CH3:1])[C:8]([OH:9])=[CH:7][CH:6]=2)[O:4][C:14](=[O:15])[CH:13]=1참가 물질
5
실험 절차
A solution of 2-methylresorcinol (1 g) in 10 mL of methyl sulfonic acid is introduced into a flask and then 1.3 equivalents (1.42 ml) of ethyl 4-chloroacetoacetate are added dropwise. After 1 night of stirring at room temperature, the mixture is cooled to 0° C. and then 50 mL of water are added. The residue is then filtered, dried and washed with diethyl ether in order to obtain 1.63 g (90%) of the compound 5.
후처리
- temperaturethe mixture is cooled to 0° C.
- filtrationThe residue is then filtered
- customdried
- washwashed with diethyl ether in order
출처 및 근거
- ORD 기록
- ord-b054d0cf8b9046979387158681a16dff
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08716496B2
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