Hydrochloric Acid → 2-(3-Bromobenzyloxy)ethanol
반응식
CC(C[AlH]CC(C)C)C.[Br:10][C:11]1[CH:12]=[C:13]([CH:17]2[O:21][CH2:20][CH2:19][O:18]2)[CH:14]=[CH:15][CH:16]=1.Cl>CCCCCCC>[Br:10][C:11]1[CH:12]=[C:13]([CH:14]=[CH:15][CH:16]=1)[CH2:17][O:18][CH2:19][CH2:20][OH:21]참가 물질
5
실험 절차
A solution of DIBAL-H in heptane is added under an inert atmosphere to a cooled (−78° C.) solution of 2-(3-bromophenyl)-1,3-dioxolane in hexanes. The reaction mixture is stirred until no starting material is seen by TLC. Aqueous HCl (1N) is added to the reaction mixture while warming to room temperature. The product is extracted with EtOAc. Combined organic layers are dried over anhydrous MgSO4, and concentrated under reduced pressure to give 2-(3-bromobenzyloxy)ethanol.
후처리
- extractionThe product is extracted with EtOAc
- dry with materialCombined organic layers are dried over anhydrous MgSO4
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-ef7c7d306204474787bef04d9ea2bd32
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08716529B2
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