Hydrochloric Acid → (S)-6-Chloro-4-(5-(2-methylpiperazin-1-yl)pyridin-2-ylamino)pyridazin-3(2H)-one

HRID 1022073노트

반응식

HRID 1022073 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[N:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][C@@H:25]3[CH3:37])=[CH:20][CH:19]=2)[C:5](=[O:16])[N:6](COCC[Si](C)(C)C)[N:7]=1.Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[CH:19]=[CH:20][C:21]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][C@@H:25]3[CH3:37])=[CH:22][N:23]=2)[C:5](=[O:16])[NH:6][N:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86684484(S)-tert-Butyl 4-(6-(6-Chloro-3-oxo-2-((2-(trimethylsilyl)ethoxy)-methyl)-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)-3-methylpiperazine-1-carboxylate

생성물 1

HCID 86684485(S)-6-Chloro-4-(5-(2-methylpiperazin-1-yl)pyridin-2-ylamino)pyridazin-3(2H)-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 50-mL round-bottomed flask was charged with 253b (551 mg, 1.0 mmol), concentrated HCl (2 mL), and methanol (10 mL). The mixture was stirred at room temperature overnight. It was then concentrated under reduced pressure to afford 253c, which was used directly in the next step without further purification. MS-ESI: [M+H]+ 321.1

후처리

  1. concentrationIt was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a213b18744604886bc160fe89d1fa00b
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716274B2

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