Sodium Hydroxide → (5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid

HRID 1022380노트

반응식

HRID 1022380 반응식
C[O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[C:9]([CH:11]2[CH2:13][CH2:12]2)[C:8]([CH3:14])=[CH:7][C:6]=1[CH3:15].[OH-].[Na+]>CO>[CH:11]1([C:9]2[C:8]([CH3:14])=[CH:7][C:6]([CH3:15])=[C:5]([CH2:4][C:3]([OH:16])=[O:2])[CH:10]=2)[CH2:12][CH2:13]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59614579(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester

생성물 1

HCID 59614593(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid수율 98.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.5 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester in 30 ml of methanol is kept at ice bath temperature and treated with 0.5 g of sodium hydroxide in 5 portions. The reaction mixture is stirred at room temperature for 1.5 hours. The solvent is removed in vacuo, the residue poured into water and extracted with diethyl ether. The combined organic phases are dried with sodium sulfate, filtered and concentrated to afford 2.3 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid.

후처리

  1. customThe solvent is removed in vacuo
  2. additionthe residue poured into water
  3. extractionextracted with diethyl ether
  4. dry with materialThe combined organic phases are dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3be7e45b54cb4d4f957656702393e31e
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722578B2

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