Sodium Hydroxide → 2-(5-Bromo-4-fluoro-2-methylphenyl)acetic acid

HRID 1022386노트

반응식

HRID 1022386 반응식
C[O:2][C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[C:9]([Br:11])[C:8]([F:12])=[CH:7][C:6]=1[CH3:13].[OH-].[Na+]>CO>[Br:11][C:9]1[C:8]([F:12])=[CH:7][C:6]([CH3:13])=[C:5]([CH2:4][C:3]([OH:14])=[O:2])[CH:10]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59614585(5-Bromo-4-fluoro-2-methyl-phenyl)-acetic acid methyl ester

생성물 1

HCID 596146012-(5-Bromo-4-fluoro-2-methylphenyl)acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of (5-bromo-4-fluoro-2-methyl-phenyl)-acetic acid methyl ester (10.3 g) in methanol (50 ml) is added 1N aqueous sodium hydroxide (47.4 ml) and the reaction mixture is stirred at room temperature for 18 hours. The mixture is concentrated, the residue treated with 1N hydrochloric acid, the resulting precipitate filtered off, washed with ice-water and dried. Yield: 8.60 g of (5-bromo-4-fluoro-2-methyl-phenyl)-acetic acid as a solid, mp: 100-101° C.

후처리

  1. concentrationThe mixture is concentrated
  2. additionthe residue treated with 1N hydrochloric acid
  3. filtrationthe resulting precipitate filtered off
  4. washwashed with ice-water
  5. customdried

출처 및 근거

ORD 기록
ord-c592fdb70c31478ba7cdc272fb3dffaa
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722578B2

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