Sodium Hydroxide → HCID 86663861, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:11][CH:10]2[C:12]([O:14]C)=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:11][CH:10]2[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8]참가 물질
4
실험 절차
To a solution of methyl (2RS,3SR)-3-(3,4-dichlorophenyl)oxirane-2-carboxylate (90.9 g) in methanol (500 ml) was added 4 N sodium hydroxide solution (138 mL), and the mixture was stirred at room temperature for 2 hr. The reaction solution was filtered and washed with methanol. To the mother liquor was added 3 N hydrochloric acid (400 ml), and the mixture was stirred at room temperature for 1 hr. The resultant product was collected by filtration, and washed with distilled water to give the title compound (57.3 g).
후처리
- filtrationThe reaction solution was filtered
- washwashed with methanol
- additionTo the mother liquor was added 3 N hydrochloric acid (400 ml)
- stirringthe mixture was stirred at room temperature for 1 hr
- filtrationThe resultant product was collected by filtration
- washwashed with distilled water
출처 및 근거
- ORD 기록
- ord-413b8b76fd204c33b7ec44d6d1870366
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08722662B2
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