Hydrochloric Acid → 2-(2-Pyridyloxy)acetic acid hydrochloride

HRID 1022732

반응식

HRID 1022732 반응식
C([O:5][C:6](=[O:15])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)(C)(C)C.[ClH:16]>C1COCC1>[ClH:16].[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][C:6]([OH:15])=[O:5]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 46168743Tert-butyl(pyridin-2-yloxy)acetate

생성물 1

HCID 669759892-(2-Pyridyloxy)acetic acid hydrochloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of tert-butyl(pyridin-2-yloxy)acetate (0.18 g) in THF (1.5 mL) was added 6 mol/L hydrochloric acid (1.5 mL) at 0° C., and the mixture was warmed to room temperature, and stirred for 2 hr. The solvent was evaporated under reduced pressure, and the resultant solid was recrystallized from ethyl acetate and diisopropyl ether to give the title compound (0.11 g).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. customthe resultant solid was recrystallized from ethyl acetate and diisopropyl ether

출처 및 근거

ORD 기록
ord-f42aa198ffd049f88bb95d785cff233c
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722662B2

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