Water → HCID 59625812, 화합물

HRID 1023127노트

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HRID 1023127 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:20](OC)(OC)OC.O>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[N:1]=[CH:20]2)=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 9005Trimethyl orthoformateHCID 59625705HCID 59625705, 화합물

생성물 1

HCID 59625812HCID 59625812, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 60d (0.18 g, 0.693 mmol) and trimethyl orthoformate (0.7 mL, 6.39 mmol) in DMF (2 mL) was refluxed for 5 h and then cooled to room temperature. Water was added to the mixture. The resulting solid was filtered, washed, with water, and dried. The crude product 60e was used in the next reaction without purification. MS m/z (M+H+) 271.1.

후처리

  1. temperaturewas refluxed for 5 h
  2. filtrationThe resulting solid was filtered
  3. washwashed, with water
  4. customdried
  5. customThe crude product 60e was used in the next reaction without purification

출처 및 근거

ORD 기록
ord-398f67a57ede4d58a32661338eba27b8
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722658B2

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