Sodium Hydroxide → HCID 43566624, 화합물

HRID 1023128노트

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HRID 1023128 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CCO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59625812HCID 59625812, 화합물

생성물 1

HCID 43566624HCID 43566624, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 60e (0.18 g, 0.666 mmol) in EtOH (10 mL) was added 1N aqueous NaOH (2.5 mL, 2.5 mmol). The mixture was stirred at room temperature for 4 d. The solvent was evaporated and 1N aqueous HCl was added, followed by extraction with EtOAc. The organic layer was dried over MgSO4 and concentrated. The crude product 60f was purified by preparative reverse phase chromatography. MS m/z (M+H+) 257.1.

후처리

  1. customThe solvent was evaporated
  2. addition1N aqueous HCl was added
  3. extractionfollowed by extraction with EtOAc
  4. dry with materialThe organic layer was dried over MgSO4
  5. concentrationconcentrated
  6. customThe crude product 60f was purified by preparative reverse phase chromatography

출처 및 근거

ORD 기록
ord-5f96de091cad41f3bc4ea3ce2cf4144d
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722658B2

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