Dimethylformamide → HCID 178505602, 화합물

HRID 1023205

반응식

HRID 1023205 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:16][C:11]2=[CH:12][N:13]=[CH:14][CH:15]=[C:10]2[CH:9]=1.[OH-:17].[Na+].[F:19][C:20]([F:31])([F:30])[O:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Cl)=[CH:24][CH:23]=1.CN([CH:35]=[O:36])C>>[F:31][C:20]([F:19])([F:30])[C:35]([O-:36])=[O:17].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[C:10]2[CH:15]=[CH:14][N:13]([CH2:26][C:25]3[CH:28]=[CH:29][C:22]([O:21][C:20]([F:19])([F:30])[F:31])=[CH:23][CH:24]=3)[CH:12]=[C:11]2[NH+:16]=1

참가 물질

5

반응물 4

HCID 6228Dimethylformamide2회HCID 14798Sodium HydroxideHCID 27772614-(Trifluoromethoxy)benzyl ChlorideHCID 57438274HCID 57438274, 화합물

생성물 1

HCID 178505602HCID 178505602, 화합물수율 8%

실험 절차

To a solution of 2-(2-Fluoro-phenyl)-1H-pyrrolo[2,3-c]pyridine (50 mg, 0.244 mmole) in DMF (1 ml) was added 10% (w/v) aqueous NaOH (113 μl, 0.28 mmole) followed by a solution of 4-trifluoromethoxybenzyl chloride (60 mg, 0.28 mmole) in DMF (0.5 ml). The reaction mixture was stirred at room temperature for 1 hour. The crude reaction mixture was purified by reverse phase HPLC with mass directed collection. Obtained 9.2 mg (8%) of 2-(2-Fluoro phenyl)-6-(4-trifluoromethoxy-benzyl)-6H-pyrrolo[2,3-c]pyridinium trifluoroacetate after repurification.

후처리

  1. customThe crude reaction mixture
  2. customwas purified by reverse phase HPLC with mass
  3. customcollection

출처 및 근거

ORD 기록
ord-892d1e4c08334499897e681f063461ce
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722677B2

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