p-Fluoronitrobenzene → 3-Chloro-5-fluorophenyl 4-nitrophenyl ether

HRID 1023506노트

반응식

HRID 1023506 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([F:8])[CH:7]=1.F[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[N+:17]([C:14]1[CH:15]=[CH:16][C:11]([O:9][C:4]2[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([Cl:1])[CH:3]=2)=[CH:12][CH:13]=1)([O-:19])=[O:18]

참가 물질

5

반응물 3

HCID 9590p-FluoronitrobenzeneHCID 11430Potassium CarbonateHCID 27737133-Chloro-5-fluorophenol

생성물 1

HCID 672358223-Chloro-5-fluorophenyl 4-nitrophenyl ether수율 88.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 3-chloro-5-fluorophenol (1.46 g, 10 mmol) and 1-fluoro-4-nitrobenzene (1.41 g, 10 mmol) in acetonitrile (40 mL) was added potassium carbonate (2.76 g, 20 mmol) and the reaction mixture was heated to reflux for 4 hours. After filtration, the solvent was removed. The residue obtained was washed with n-hexane (2 times 15 mL) and dried to afford the title compound (2.38 g) which was directly used in the next step.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 4 hours
  3. filtrationAfter filtration
  4. customthe solvent was removed
  5. customThe residue obtained
  6. washwas washed with n-hexane (2 times 15 mL)
  7. customdried

출처 및 근거

ORD 기록
ord-dd2b611e9da64415b595deecef9380eb
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722695B2

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