Benzylamine → benzyl-[5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-amine

HRID 1024153노트

반응식

HRID 1024153 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:10]1[N:15]=[CH:14][C:13]([CH2:16][C:17]2[C:25]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[N:19]([Si](C(C)C)(C(C)C)C(C)C)[CH:18]=2)=[CH:12][CH:11]=1.BrC1N=CC(CC2C3C(=NC=CC=3)N([Si](C(C)C)(C(C)C)C(C)C)C=2)=CC=1>>[CH2:1]([NH:8][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][C:17]2[C:25]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)=[CH:14][N:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 7504BenzylamineHCID 575880773-(6-Chloro-pyridin-3-ylmethyl)-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridineHCID 584421163-(6-Bromo-pyridin-3-ylmethyl)-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 11551410benzyl-[5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-amine

실험 절차

The following table indicates the amine used in Step 1 in place of benzyl amine in Column 3, and whether 3-(6-Chloro-pyridin-3-ylmethyl)-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine or 3-(6-Bromo-pyridin-3-ylmethyl)-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine was used in Step 1 in Column 2 (Cl or Br, respectively), with the compound structure in Column 4, experimental mass spectrometry result in Column 5, and compound number in Column 1.

후처리

  1. customrespectively), with the compound structure in Column 4, experimental mass spectrometry result in Column 5, and compound number in Column 1

출처 및 근거

ORD 기록
ord-1f4eb0f155cf4c14a9f81e0d0f7f2f11
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722702B2

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