Sodium borohydride → 3-Chloro-1-(2-thienyl)-1-propanol

HRID 1024482노트

반응식

HRID 1024482 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[CH2:7][CH2:8][Cl:9].[BH4-].[Na+]>C(O)C>[Cl:9][CH2:8][CH2:7][CH:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[OH:10]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 75678553-Chloro-1-(2-thienyl)-1-propanone

생성물 1

HCID 116583743-Chloro-1-(2-thienyl)-1-propanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

For example, a method is known wherein 1-(2-thienyl)-3-chloropropan-1-one is reduced using sodium borohydride in ethanol to obtain 3-chloro-1-(2-thienyl)-1-propanol, halogen exchange is subsequently conducted in acetone using sodium iodide to obtain 3-iodo-1-(2-thienyl)-1-propanol, and then this is reacted with a monomethylamine aqueous solution in tetrahydrofuran (CHIRALITY, 12, 26-29 (2000)). However, since the raw material used in this method is 1-(2-thienyl)-3-chloropropan-1-one, which is a very unstable compound, this method is not industrially applicable.

출처 및 근거

ORD 기록
ord-4468c15f9511432f9b12f9e957049382
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722906B2

반응 노트

불러오는 중…