Hydrochloric Acid → 1-(Pyridazin-3-yl)cyclopropanamine hydrochloride
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([NH:10]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[N:2]=1.[ClH:18]>C1COCC1.O1CCOCC1>[ClH:18].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([NH2:10])[CH2:9][CH2:8]2)[N:2]=1참가 물질
5
실험 절차
To a solution of tert-butyl 1-(pyridazin-3-yl)cyclopropylcarbamate (0.3 g) in THF (3 ml) at 0° C. was added HCl in dioxane (5 ml) and the mixture stirred at r.t. for 3 hr. The reaction mixture was concentrated, and the crude product was taken for the next coupling reaction. Yield: 0.21 g
후처리
- concentrationThe reaction mixture was concentrated
- customthe crude product was taken for the next coupling reaction
출처 및 근거
- ORD 기록
- ord-8bba017bfafe41da8ef57042adcdc905
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08722688B2
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