Hydrochloric Acid → 1-(Pyrimidin-4-yl)cyclopropan-1-amine hydrochloride

HRID 1025238노트

반응식

HRID 1025238 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH:10]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)=[N:3][CH:2]=1.[ClH:18]>O1CCOCC1>[ClH:18].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH2:10])[CH2:9][CH2:8]2)=[N:3][CH:2]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67292536(1-Pyrimidin-4-yl-cyclopropyl)-carbamic acid tert-butyl ester

생성물 1

HCID 672924411-(Pyrimidin-4-yl)cyclopropan-1-amine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of tert-butyl 1-(pyrimidin-4-yl)cyclopropylcarbamate (0.100 g, 0.425 mmol, 1.0 eq), in 4.0 M HCl in 1,4-dioxane (4.0 ml) was stirred at r.t. for 5 hr. The reaction mixture was concentrated completely and the HCl salt was taken to next step.

후처리

  1. concentrationThe reaction mixture was concentrated completely

출처 및 근거

ORD 기록
ord-16cc59ecc25343ceab77223f44ab138a
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722688B2

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