Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | tert-butyl (2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxopentan-3-ylcarbamate | HCID 86762402 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride | HCID 86762404 | — |
반응 단계
Under an atmosphere of argon, tert-butyl (2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxopentan-3-ylcarbamate (540 mg, 1.98 mmol) and HCl 4N in dioxane (10.4 ml) were combined to give a light brown solution. The reaction was stirred for 4 h at RT. The solvent was evaporated. The residual solvent was removed under vacuum. The title compound was obtained as a brown solid (480 mg, quant., MS (m/e)=173.2 [M+H+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08729061B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-e5fea5f5dde2408fbb40d99a5bfb0f8a |
| 출처 메모 | uspto-grants-2014_05 |