Acetic Anhydride → 2-acetamido-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one

HRID 1025517노트

반응식

HRID 1025517 반응식
[NH2:1][C:2]1[NH:3][C:4](=[O:19])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C(O)(=O)C>[C:20]([NH:1][C:2]1[NH:3][C:4](=[O:19])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1)(=[O:22])[CH3:21]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 1361375922-Amino-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4(1H)-one

생성물 1

HCID 1360008912-acetamido-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one수율 78%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A suspension of 2-amino-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one (2.0 g) in acetic anhydride (180 ml) and acetic acid (20 ml) was refluxed for 16 hours. The hot suspension was filtered and the filtrate was concentrated under reduced pressure until crystallization started. The precipitate was filtered off to give the pure title compound in 78% yield. The compound was characterized by its mass spectrum as follows: MS (m/z): 299 ([M+H]+, 100).

후처리

  1. temperaturewas refluxed for 16 hours
  2. filtrationThe hot suspension was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure until crystallization
  4. filtrationThe precipitate was filtered off

출처 및 근거

ORD 기록
ord-7638cfebe31e4703a5e4cd0c223121e1
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729089B2

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