Cyclopropanecarbonyl chloride → Ethyl 4-(cyclopropanecarbonyl)benzoate

HRID 1025799

반응식

[I-].[CH2:2]([O:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([Zn+])=[CH:9][CH:8]=1)=[O:6])[CH3:3].[CH:14]1([C:17](Cl)=[O:18])[CH2:16][CH2:15]1>>[CH:14]1([C:17]([C:10]2[CH:11]=[CH:12][C:7]([C:5]([O:4][CH2:2][CH3:3])=[O:6])=[CH:8][CH:9]=2)=[O:18])[CH2:16][CH2:15]1

참가 물질

반응물 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 178469116HCID 178469116, 화합물

생성물 1

HCID 24724092Ethyl 4-(cyclopropanecarbonyl)benzoate

실험 절차

Intermediate i-3a was prepared from 4-ethoxycarbonylphenyl zinc iodide and cyclopropanecarbonyl chloride following the above procedure as described for intermediate i-1a. m/z (ES) 219 (MH)+. 1HNMR (500 MHz, CDCl3): δ 8.17 (d, 2H, J=8.5 Hz), 8.08 (d, 2H, J=8.4 Hz), 4.44 (q, 2H, J=7.1 Hz), 2.71 (m, 1H), 1.45 (t, 3H, J=7.1 Hz), 1.31 (m, 2H), 1.13 (m, 2H).

출처 및 근거

ORD 기록: ord-7c88169332de4cee8e017c1347355d2a
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08729104B2

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