Potassium Carbonate → HCID 86666271, 화합물

HRID 1026239노트

반응식

HRID 1026239 반응식
Br[CH2:2][CH:3]1[CH2:5][CH2:4]1.[Br:6][C:7]1[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:8]=1[CH2:14][C:15]([OH:17])=[O:16].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:6][C:7]1[CH:12]=[C:11]([O:13][CH2:2][CH:3]2[CH2:5][CH2:4]2)[CH:10]=[CH:9][C:8]=1[CH2:14][C:15]([O:17][CH2:2][CH:3]1[CH2:5][CH2:4]1)=[O:16]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 81503BromomethylcyclopropaneHCID 24721648(2-Bromo-4-hydroxyphenyl)acetic acid

생성물 1

HCID 86666271HCID 86666271, 화합물수율 89.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of (bromomethyl)cyclopropane (10.52 g), (2-bromo-4-hydroxyphenyl)acetic acid (6.0 g) and potassium carbonate (7.18 g) in DMF (200 mL) was stirred at 80° C. for 8 hr. The reaction mixture was allowed to cool to room temperature, and the solvent was evaporated under reduced pressure. The residue was diluted with diethyl ether and water, and the organic layer was separated. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (7.89 g).

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. additionThe residue was diluted with diethyl ether and water
  3. customthe organic layer was separated
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-94c7ae5292e242dc90446a9558102a27
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729102B2

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