6-Aminoindole → 3-Ethoxycarbonyl-7-(6-indolylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine

HRID 1026984

반응식

HRID 1026984 반응식
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17].[NH2:30][C:31]1[CH:39]=[C:38]2[C:34]([CH:35]=[CH:36][NH:37]2)=[CH:33][CH:32]=1>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:30][C:31]3[CH:39]=[C:38]4[C:34]([CH:35]=[CH:36][NH:37]4)=[CH:33][CH:32]=3)=[C:3]([C:16]([N:18]3[CH2:23][CH2:22][CH:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:20][CH2:19]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

참가 물질

3

반응물 2

HCID 2560966-AminoindoleHCID 866462907-Chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine

생성물 1

HCID 675412573-Ethoxycarbonyl-7-(6-indolylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine수율 98%

실험 절차

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine (0.15 g, 0.36 mmol) obtained in Example 19, step 4 and 6-aminoindole (0.054 g, 0.72 mmol), the title compound (0.179 g, 98%) was obtained.

출처 및 근거

ORD 기록
ord-162607e6c9a7454b976db740cff046be
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729264B2

연결된 노트

불러오는 중…