3-Bromobenzophenone → (3-Bromophenyl)(phenyl)methanol

HRID 1027448노트

반응식

HRID 1027448 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[BH4-].[Na+]>CO.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[OH:6])[CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 2

HCID 705483-BromobenzophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 285827(3-Bromophenyl)(phenyl)methanol수율 79%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of 3-bromobenzophenone (1.00 g, 4 mmol) in MeOH (15 mL) was added sodium borohydride (0.3 mL, 8 mmol) portionwise at rt and the suspension was stirred at rt for 1-24 h. The reaction was diluted slowly with water and extracted with CH2Cl2. The organic layer was washed successively with water, brine, dried over Na2SO4, and concentrated to give the title compound as oil (0.8 g, 79%), which was used in the next reaction without further purification. MS (ESI, pos. ion) m/z: 247.1 (M-OH).

후처리

  1. extractionextracted with CH2Cl2
  2. washThe organic layer was washed successively with water, brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8d410541761445d0900f5484df9ca106
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735383B2

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