Hydroxyamine hydrochloride → 5-Bromo-4-methyl-pyridine-2-carbaldehyde oxime

HRID 1027594노트

반응식

HRID 1027594 반응식
[Br:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([CH:8]=O)=[N:6][CH:7]=1.Cl.[NH2:12][OH:13].C([O-])(=O)C.[Na+]>CCO.O>[Br:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([CH:8]=[N:12][OH:13])=[N:6][CH:7]=1

참가 물질

6

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 594745005-Bromo-4-methylpicolinaldehyde

생성물 1

HCID 1363413885-Bromo-4-methyl-pyridine-2-carbaldehyde oxime수율 66%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of the compound obtained in Step B (3.1 g) in EtOH (47.5 ml) and water (23 ml) were added hydroxylamine hydrochloride (1.4 g) and sodium acetate (1.9 g). The reaction was stirred for 15 min at room temperature. The white solid was filtered off and the solution concentrated in vacuo to afford the crude title product (2.2 g, white solid), which was used directly for the next step. LCMS (Method F) 2.09 min, M+H 564/566.

후처리

  1. filtrationThe white solid was filtered off
  2. concentrationthe solution concentrated in vacuo

출처 및 근거

ORD 기록
ord-81b2912c0bab483b8928743b60cccea6
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735362B2

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