Hydrochloric Acid → HCID 178418398, 화합물

HRID 1028

반응식

HRID 1028 반응식
Cl[C:2]1[C:7]([Br:8])=[C:6]([NH:9][C@H:10]2[CH2:15][CH2:14][C@@H:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH:5]=[CH:4][N:3]=1.[CH3:22][O-:23].[Na+].O.Cl>CN(C)C=O.CO>[CH3:22][O:23][C:2]1[C:7]([Br:8])=[C:6]([NH:9][C@H:10]2[CH2:15][CH2:14][C@@H:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH:5]=[CH:4][N:3]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 10942334Sodium MethoxideHCID 178418294HCID 178418294, 화합물

생성물 1

HCID 178418398HCID 178418398, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

2.21 g (6.04 mmol) of 2-chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine in 30 ml of dimethylformamide are treated with 4.31 ml of 30% strength solution of sodium methoxide in methanol and the mixture is heated at 80° C. for 1 hour. After cooling, water is added, the mixture is adjusted to pH 8 using 1/2 conc. hydrochloric acid and the reaction product is extracted with ethyl acetate. For purification it is chromatographed. Yield: 1.72 g (79%); Rf =0.4 (diisopropyl ether)

후처리

  1. temperatureAfter cooling
  2. extractionthe reaction product is extracted with ethyl acetate
  3. customFor purification it
  4. customis chromatographed

출처 및 근거

ORD 기록
ord-5a04f014ea6d40c2b125f6974f5951e3
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723450

연결된 노트

불러오는 중…