(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone → 1-(2,3-Dimethylphenyl)-2-phenyl-1-(1-trityl-1h-imidazol-5-yl)ethanol

HRID 1028192

반응식

HRID 1028192 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[N:15]([C:16]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:14]=[N:13][CH:12]=1)=[O:10].[CH2:35]([Mg]Br)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>ClCCl>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[N:15]([C:16]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:14]=[N:13][CH:12]=1)([OH:10])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

참가 물질

4

반응물 2

HCID 42631463(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanoneHCID 178419663HCID 178419663, 화합물

생성물 1

HCID 574376781-(2,3-Dimethylphenyl)-2-phenyl-1-(1-trityl-1h-imidazol-5-yl)ethanol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of (2,3-dimethylphenyl)(I-trityl-1H imidazol-5-yl)methanone (450 mg, 1.01 mmol) in dichloromethane (25 mL) at room temperature was treated with benzyl magnesium bromide (1.51 mmol) and allowed to react at room temperature and the reaction mixture was then stirred at room temperature for 5 hours. The mixture was quenched with water (10 mL) and a sat. solution of ammonium chloride (10 mL). The residue was isolated in a typical aqueous to give 1-(2,3-dimethylphenyl)-2-phenyl-1-(1-trityl-1H-imidazol-5-yl)ethanol (Intermediate 8) crude, which was taken to the next step without any purification.

후처리

  1. customto react at room temperature
  2. customThe mixture was quenched with water (10 mL)
  3. customThe residue was isolated in a typical aqueous

출처 및 근거

ORD 기록
ord-6ef30ff6861c404196202d8c13e54eb8
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735438B2

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