Hydrochloric Acid → Methyl 2-(4-oxocyclohexyl)acetate

HRID 1028200노트

반응식

HRID 1028200 반응식
Cl.[CH3:2][O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1>CC(C)=O>[CH3:2][O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:15][CH2:14][C:9](=[O:10])[CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 20711792Methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate

생성물 1

HCID 21249113Methyl 2-(4-oxocyclohexyl)acetate수율 108.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A 1 N aqueous hydrochloric acid solution (50 mL)/acetone (200 ml) mixture of (1,4-dioxa-spiro[4.5]dec-8-yl)-acetic acid methyl ester (4.99 g) obtained in Example (1b) was stirred at room temperature for 15 hours. The organic solvent was removed using an evaporator. The remaining aqueous solution was subjected to two extractions with ethyl acetate. The organic layer was washed with saturated brine, then dried over sodium sulfate, and then concentrated to obtain the title compound (4.30 g, quantitative yield) as a colorless oil.

후처리

  1. customThe organic solvent was removed
  2. customan evaporator
  3. extractionThe remaining aqueous solution was subjected to two extractions with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fb35a696927b494fbeb28c853f0474a5
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735425B2

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