Bromine → 6-Amino-5-bromopyridine-3-carbonitrile

HRID 1028307

반응식

HRID 1028307 반응식
[Br:1]Br.[NH2:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][N:5]=1>CC(O)=O>[NH2:3][C:4]1[C:11]([Br:1])=[CH:10][C:7]([C:8]#[N:9])=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 8182602-Amino-5-cyanopyridine

생성물 1

HCID 14912506-Amino-5-bromopyridine-3-carbonitrile수율 49.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Br2 (0.52 mL, 0.01 mol) was added to a solution of 6-aminonicotinonitrile (1.1901 g, 0.01 mol) in AcOH (10 mL) at room temperature. The mixture was stirred at room temperature for 2 h. Then the mixture was concentrated and the residue was purified by flash column chromatography to give the title product (980.0 mg, 49%).

후처리

  1. concentrationThen the mixture was concentrated
  2. customthe residue was purified by flash column chromatography

출처 및 근거

ORD 기록
ord-1f7dffa32c274d558d4b0459e33724d8
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735440B2

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