Diisopropylcarbodiimide → N,N'-Bis(1-methylethyl)urea

HRID 1028859

반응식

HRID 1028859 반응식
Cl.C([O:4]C(=O)[C@H](CC1C=CC=CC=1)N)C.[CH:16]([N:19]=[C:20]=[N:21][CH:22]([CH3:24])[CH3:23])([CH3:18])[CH3:17].C(N(C(C)C)CC)(C)C>O>[CH:16]([NH:19][C:20](=[O:4])[NH:21][CH:22]([CH3:24])[CH3:23])([CH3:18])[CH3:17]

참가 물질

5

반응물 3

HCID 12734DiisopropylcarbodiimideHCID 81531DiisopropylethylamineHCID 165085Ethyl L-phenylalaninate hydrochloride

생성물 1

HCID 20084N,N'-Bis(1-methylethyl)urea

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Then 11.5 g (50 mM) of Phenylalanine Ethyl Ester hydrochloride and 7.75 mL (45 mM) of diisopropylcarbodiimide were added. Then 8.6 mL (50 mM) of diisopropylethylamine was added via the dropping funnel for 10 min. The reaction mixture was kept for 20 hours at a room temperature, then 10 mL of H2O was added, a precipitate of diisopropylurea formed was filtered off, a resulted solution was analyzed by HPLC. According analysis, the reaction was completed at 50%.

출처 및 근거

ORD 기록
ord-f920496197c1476e8361f7ae5bb4c5a4
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735623B2

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