Oxalyl chloride → 2-Bromo-3-methylbenzoyl chloride
반응식
[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl>[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
A suspension of 2-bromo-3-methylbenzoic acid (2.07 g, 9.63 mmol) in DCM (48.1 mL) was cooled to 0° C. Oxalyl chloride (0.9 mL, 10.14 mmol) was added dropwise via syringe. After addition, the cooling bath was removed and the reaction mixture stirred overnight. The mixture was concentrated in vacuo to remove solvent and excess reagent, affording 2-bromo-3-methylbenzoyl chloride as a cloudy white oil.
후처리
- additionAfter addition
- customthe cooling bath was removed
- concentrationThe mixture was concentrated in vacuo
- customto remove solvent and excess reagent
출처 및 근거
- ORD 기록
- ord-83032d37c54a46f5b993f92c72bb64b3
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08735384B2
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