Oxalyl chloride → 2-Bromo-3-methylbenzoyl chloride

HRID 1028940

반응식

HRID 1028940 반응식
[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl>[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 27355882-Bromo-3-methylbenzoic acid

생성물 1

HCID 141743752-Bromo-3-methylbenzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

A suspension of 2-bromo-3-methylbenzoic acid (2.07 g, 9.63 mmol) in DCM (48.1 mL) was cooled to 0° C. Oxalyl chloride (0.9 mL, 10.14 mmol) was added dropwise via syringe. After addition, the cooling bath was removed and the reaction mixture stirred overnight. The mixture was concentrated in vacuo to remove solvent and excess reagent, affording 2-bromo-3-methylbenzoyl chloride as a cloudy white oil.

후처리

  1. additionAfter addition
  2. customthe cooling bath was removed
  3. concentrationThe mixture was concentrated in vacuo
  4. customto remove solvent and excess reagent

출처 및 근거

ORD 기록
ord-83032d37c54a46f5b993f92c72bb64b3
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735384B2

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