Sodium borohydride → (2-(2-amino-3-morpholinoquinolin-6-yl)phenyl)(tetrahydro-2H-pyran-4-yl)methanol

HRID 1028956노트

반응식

HRID 1028956 반응식
[NH2:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]([CH:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[O:25])[CH:8]=2)[N:3]=1.[BH4-].[Na+]>CO>[NH2:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[CH:24]([CH:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)[OH:25])[CH:8]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 53328643(2-(2-amino-3-morpholinoquinolin-6-yl)phenyl)(tetrahydro-2H-pyran-4-yl)methanone

생성물 1

HCID 53328818(2-(2-amino-3-morpholinoquinolin-6-yl)phenyl)(tetrahydro-2H-pyran-4-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

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온도
40 °C

실험 절차

(2-(2-Amino-3-morpholinoquinolin-6-yl)phenyl)(tetrahydro-2H-pyran-4-yl)methanone (0.164 g, 0.393 mmol, see Example 11) was dissolved in MeOH (20 mL) and treated with sodium borohydride (0.021 mL, 0.589 mmol). After 10 min, the solution was heated to 40° C. for an additional 15 minutes, then evaporated to dryness under reduced pressure. The crude material was partitioned between water (20 mL), saturated sodium bicarbonate (20 mL), and ethyl acetate (40 mL). The organic layer was dried with magnesium sulfate and evaporated to dryness under reduced pressure and the crude material was purified by silica chromatography (10-100% hexane in ethyl acetate gradient. The product peak which eluted was concentrated to give (2-(2-amino-3-morpholinoquinolin-6-yl)phenyl)(tetrahydro-2H-pyran-4-yl)methanol. MS (ESI, pos. ion) m/z: 420 (M+1).

후처리

  1. customevaporated to dryness under reduced pressure
  2. customThe crude material was partitioned between water (20 mL), saturated sodium bicarbonate (20 mL), and ethyl acetate (40 mL)
  3. dry with materialThe organic layer was dried with magnesium sulfate
  4. customevaporated to dryness under reduced pressure
  5. customthe crude material was purified by silica chromatography (10-100% hexane in ethyl acetate gradient
  6. washThe product peak which eluted
  7. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-3343a55476b84d8eb2700d35ebb8f61a
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735384B2

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