(2-(2-Amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrazin-2-yl)methanol → 6-(2-Methyl-6-(pyrazin-2-ylmethyl)phenyl)-3-morpholinoquinolin-2-amine

HRID 1029012노트

반응식

HRID 1029012 반응식
[NH2:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:18]3[C:23]([CH3:24])=[CH:22][CH:21]=[CH:20][C:19]=3[CH:25]([C:27]3[CH:32]=[N:31][CH:30]=[CH:29][N:28]=3)O)[CH:8]=2)[N:3]=1>CC(O)C.Cl>[CH3:24][C:23]1[CH:22]=[CH:21][CH:20]=[C:19]([CH2:25][C:27]2[CH:32]=[N:31][CH:30]=[CH:29][N:28]=2)[C:18]=1[C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH2:1])[C:11]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[CH:10]2

참가 물질

4

반응물 1

HCID 53329361(2-(2-Amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrazin-2-yl)methanol

생성물 1

HCID 533295356-(2-Methyl-6-(pyrazin-2-ylmethyl)phenyl)-3-morpholinoquinolin-2-amine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 3776Isopropanol용매

실험 절차

A solution of (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrazin-2-yl)methanol (0.040 g, 0.094 mmol, prepared as Example 36 above) in i-PrOH and 5N HCl (15 mL) was refluxed for 15 h, or until starting material was consumed. The mixture was brought to RT, carefully washed with 5N NaOH and extracted with DCM. The combined organics were dried over Na2SO4, filtered, concentrated and purified by HPLC to afford a light brown solid as 6-(2-methyl-6-(pyrazin-2-ylmethyl)phenyl)-3-morpholinoquinolin-2-amine. MS (ESI, pos. ion) m/z: 412 (M+1).

후처리

  1. customwas consumed
  2. customwas brought to RT
  3. washcarefully washed with 5N NaOH
  4. extractionextracted with DCM
  5. dry with materialThe combined organics were dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. custompurified by HPLC

출처 및 근거

ORD 기록
ord-dadd8309185f473997c5711979b742ed
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735384B2

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