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Water → 2-[4-bromo-5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyrimidine

HRID 1029466
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HRID 1029466 반응식
[Br:1]N1C(=O)CCC1=O.[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]([C:21]3[N:26]=[CH:25][CH:24]=[CH:23][N:22]=3)[N:19]=[C:18]([CH:27]([CH3:29])[CH3:28])[CH:17]=2)=[CH:12][CH:11]=1.O>CN(C=O)C>[Br:1][C:17]1[C:18]([CH:27]([CH3:29])[CH3:28])=[N:19][N:20]([C:21]2[N:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[C:16]=1[C:13]1[CH:14]=[CH:15][C:10]([F:9])=[CH:11][CH:12]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 148513212-[5-(4-Fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyrimidine

생성물 1

HCID 148513232-[4-bromo-5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyrimidine수율 82.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-Bromosuccinimide (9.97 g, 0.056 mol) was added to a solution of 2-[5-(4-fluorophenyl)-3-(l-methylethyl)-1H-pyrazol-1-yl]pyrimidine (15.8 g, 0.056 mol) in DMF at 0° C. The resulting mixture was allowed to warm to room temperature over 24 hours. This was then poured into 500 mL water. The white solid which precipitated was collected by filtration and dried to yield 16.7 g of 2-[4-bromo-5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyrimidine (3), mp 130°-133° C.

후처리

  1. customThe white solid which precipitated
  2. filtrationwas collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-1cf6b2647cab4f7fbb85b89b9c8d439b
출처 데이터셋
uspto-grants-1992_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05102893

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