Sodium Hydroxide → 1-(Diphenylmethyl)azetidine-3-carboxylic acid

HRID 1029635노트

반응식

HRID 1029635 반응식
[C:1]1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:8]2[CH2:11][CH:10]([C:12]([O:14]C)=[O:13])[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.O1CCCC1>[C:16]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]2[CH2:11][CH:10]([C:12]([OH:14])=[O:13])[CH2:9]2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 2759842Methyl 1-(diphenylmethyl)azetidine-3-carboxylate

생성물 1

HCID 27354401-(Diphenylmethyl)azetidine-3-carboxylic acid수율 92.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-(diphenylmethyl)-3-methoxycarbonylazetidine (28 g) in methanol (270 ml) and tetrahydrofuran (130 ml) was added 1N sodium hydroxide (115 ml) and the solution was stirred at room temperature for 1.5 hours. The solution was then concentrated to remove organic solvents under reduced pressure. The resultant aqueous solution was adjusted to pH 2.95 with 10% hydrochloric acid, and resulting precipitates were collected by filtration, washed with water and dried to give 1-(diphenylmethyl)-3-carboxyazetidine (24.7 g).

후처리

  1. concentrationThe solution was then concentrated
  2. customto remove organic solvents under reduced pressure
  3. customresulting
  4. customprecipitates
  5. filtrationwere collected by filtration
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-eb6769a95d484a969b52426dd2c14f2b
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05102877

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