1-(Thiophen-3-yl)ethanone → 3-Dimethylamino-1-thien-3-ylpropen-1-one

HRID 1029804

반응식

HRID 1029804 반응식
[C:1]([C:4]1[CH:8]=[CH:7][S:6][CH:5]=1)(=[O:3])[CH3:2].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH3:14])[CH:13]=[CH:2][C:1]([C:4]1[CH:8]=[CH:7][S:6][CH:5]=1)=[O:3]

참가 물질

3

반응물 2

HCID 151161-(Thiophen-3-yl)ethanoneHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 5964663-Dimethylamino-1-thien-3-ylpropen-1-one수율 87%

실험 절차

A mixture of 48.4 g of 3-acetylthiophene and 75 ml of dimethylformamide dimethyl acetal, under nitrogen, is heated for 15 hours on a steam bath. The reaction is concentrated in vacuo and the residue crystallized from methylene chloride/hexane to give 60.55 g (87%) of the desired product, mp 89°-90° C.

후처리

  1. temperatureunder nitrogen, is heated for 15 hours on a steam bath
  2. concentrationThe reaction is concentrated in vacuo
  3. customthe residue crystallized from methylene chloride/hexane

출처 및 근거

ORD 기록
ord-fe6e3ea10657422eb07a3e6e988e0ae0
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05103015

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