2-Ethoxyphenol → 2-Ethoxyphenoxysulfonyl isocyanate

HRID 1030006노트

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HRID 1030006 반응식
Cl[S:2]([N:5]=[C:6]=[O:7])(=[O:4])=[O:3].[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[OH:17])[CH3:9]>C1(C)C(C)=CC=CC=1>[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][S:2]([N:5]=[C:6]=[O:7])(=[O:4])=[O:3])[CH3:9]

참가 물질

4

반응물 2

HCID 667552-EthoxyphenolHCID 70918Chlorosulfonyl isocyanate

생성물 1

HCID 190299582-Ethoxyphenoxysulfonyl isocyanate

시약·촉매·용매 1

HCID 7237O-Xylene용매

반응 조건

온도
140 °C

실험 절차

67.9 g (0.48 mol) of chlorosulfonyl isocyanate are added dropwise at 25° C. to a solution of 55.2 g (0.4 mol) of 2-ethoxyphenol in 500 ml of xylene. When the dropwise addition is complete, the temperature is increased slowly to 140° C. and the mixture is refluxed for 2.5 hours. The mixture is cooled, and the solvent as well as excess chlorosulfonyl isocyanate are removed on a rotary evaporator. The yellow oil which remains (97.2 g=100% of theory) is employed without further purification.

후처리

  1. additionWhen the dropwise addition
  2. temperaturethe mixture is refluxed for 2.5 hours
  3. temperatureThe mixture is cooled
  4. customthe solvent as well as excess chlorosulfonyl isocyanate are removed on a rotary evaporator
  5. customis employed without further purification

출처 및 근거

ORD 기록
ord-aec70c62939d41d5a380f35e73bc23fc
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104443

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