HCID 668793, 화합물 → 4-hydroxy-N,N-dimethylbenzenesulfonamide
반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10])=[CH:5][CH:4]=1참가 물질
4
실험 절차
A mixture of 4-methoxy-N,N-dimethylbenzenesulfonamide (37 g) and aluminum chloride (69 g) in benzene (170 ml) was stirred under reflux for 30 minutes. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over anhydrous magnesium sulfate, and concentrated. The residue was purified by recrystallization from toluene to give 4-hydroxy-N,N-dimethylbenzenesulfonamide (26 g).
후처리
- temperatureunder reflux for 30 minutes
- extractionextracted with ethyl acetate
- washThe combined organic layers were washed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated
- customThe residue was purified by recrystallization from toluene
출처 및 근거
- ORD 기록
- ord-a7aa49b1789841658b301a6856c6a887
- 출처 데이터셋
- uspto-grants-1992_04
- 특허 번호
- US05104890
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