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Sodium Hydroxide → 1-Chloro-3-(4-aminophenoxy)propane

HRID 1030274
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HRID 1030274 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1.[OH-].[Na+]>CCO>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1
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참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 118446171-(3-Chloropropoxy)-4-nitrobenzene

생성물 1

HCID 198223581-Chloro-3-(4-aminophenoxy)propane수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-chloro-3-(4-nitrophenoxy)propane (830 mg, 3.85 mmol), stannous chloride dihydrate (4.3 g, 19.25 mmol), and EtOH (20 mL) was heated under reflux for 3 hours. The mixture was cooled, 2.5N NaOH (19 mL) was added, and the precipitate was removed by filtration. The filtrate was concentrated to 10 mL and extracted with EtOAc. The extracts were dried (MgSO4) and concentrated to give 700 mg (98%) of product as a brown oil.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. temperatureThe mixture was cooled
  4. customthe precipitate was removed by filtration
  5. concentrationThe filtrate was concentrated to 10 mL
  6. extractionextracted with EtOAc
  7. dry with materialThe extracts were dried (MgSO4)
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a4a9a3e2a9ec4d1cbadba9c6902fe7d1
출처 데이터셋
uspto-grants-1992_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05104892

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