참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | 3-Chloropropanethiol | HCID 87134 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 14933055 | HCID 14933055 | 34% |
반응 단계
To a cooled (10° C.), stirred suspension of KOtBu (8.9 g, 0.080 mol) in DMSO (40 mL) was added a solution of 4-fluoronitrobenzene (11.2 g, 0.080 mol) and 3-chloropropanethiol (8.8 g, 0.080 mol) in DMSO (40 mL) over 10 minutes. The mixture was stirred at room temperature for 3.5 hours, diluted with water (1000 ml), and extracted with ether. The extracts were washed with brine, dried (MgSO4), and concentrated. Purification by flash chromatography (10% EtOAc/hexane) gave 6.2 g (34%) of product as a yellow solid m.p. 45°-48° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05104892 |
|---|
| 출처 데이터셋 | uspto-grants-1992_04 |
|---|
| ORD ID | ord-7e3d4cb3d6324a3a900fd6ef81d27707 |
|---|
| 출처 메모 | uspto-grants-1992_04 |
|---|
