Hydrochloric Acid → alpha-{5-[4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]-2,4-dioxothiazolidin-3yl}acetic acid

HRID 1030387노트

반응식

HRID 1030387 반응식
[OH:1][C:2]1[C:3]([CH3:39])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH2:15][O:16][C:17]1[CH:38]=[CH:37][C:20]([CH2:21][CH:22]3[S:26][C:25](=[O:27])[N:24]([CH2:28][C:29]([O:31]C(C)(C)C)=[O:30])[C:23]3=[O:36])=[CH:19][CH:18]=1)([CH3:14])[CH2:6][CH2:5]2.Cl>O1CCOCC1>[OH:1][C:2]1[C:3]([CH3:39])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH2:15][O:16][C:17]1[CH:38]=[CH:37][C:20]([CH2:21][CH:22]3[S:26][C:25](=[O:27])[N:24]([CH2:28][C:29]([OH:31])=[O:30])[C:23]3=[O:36])=[CH:19][CH:18]=1)([CH3:14])[CH2:6][CH2:5]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 19822185t-Butyl alpha-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3-yl}acetate

생성물 1

HCID 19822231alpha-{5-[4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]-2,4-dioxothiazolidin-3yl}acetic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 1.0 g of t-butyl α-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl ]-2,4-dioxothiazolidin-3-yl}acetate (prepared as described in Example 46) and 10 ml of a 4N dioxane solution of hydrogen chloride was allowed to stand at room temperature overnight. At the end of this time, the solvent was distilled off and the residue was washed with water to give the title compound as a pale yellow powder, softening at 85°-90° C.

후처리

  1. distillationAt the end of this time, the solvent was distilled off
  2. washthe residue was washed with water

출처 및 근거

ORD 기록
ord-babe3a4713d34b24aeae93870948c4dc
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104888

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