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Hydrochloric Acid → Ethyl 2-chloro-3-[4-(6-ethoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenyl]propionate

HRID 1030433
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인쇄 미리보기

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HRID 1030433 반응식
N[C:2]1[CH:26]=[CH:25][C:5]([O:6][CH2:7][C:8]2([CH3:24])[CH2:17][CH2:16][C:15]3[C:10](=[C:11]([CH3:23])[C:12]([CH3:22])=[C:13]([O:19][CH2:20][CH3:21])[C:14]=3[CH3:18])[O:9]2)=[CH:4][CH:3]=1.[ClH:27].N([O-])=O.[Na+].[C:32]([O:36][CH2:37][CH3:38])(=[O:35])[CH:33]=[CH2:34]>CC(C)=O>[Cl:27][CH:33]([CH2:34][C:2]1[CH:26]=[CH:25][C:5]([O:6][CH2:7][C:8]2([CH3:24])[CH2:17][CH2:16][C:15]3[C:10](=[C:11]([CH3:23])[C:12]([CH3:22])=[C:13]([O:19][CH2:20][CH3:21])[C:14]=3[CH3:18])[O:9]2)=[CH:4][CH:3]=1)[C:32]([O:36][CH2:37][CH3:38])=[O:35]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 198221972-(4-Aminophenoxymethyl)-6-ethoxy-2,5,7,8-tetramethylchromanHCID 23668193Sodium Nitrite

생성물 1

HCID 19822269Ethyl 2-chloro-3-[4-(6-ethoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenyl]propionate

시약·촉매·용매 1

HCID 180
Acetone
용매

실험 절차

The procedure described in Preparation 64 was repeated, except that 9.5 g of 2-(4-aminophenoxymethyl)-6-ethoxy-2,5,7,8-tetramethylchroman (prepared as described in Preparation 63), 10 ml of concentrated hydrochloric acid, 2.4 g of sodium nitrite, 26.8 g of ethyl acrylate, 0.4 g of cuprous oxide and 100 ml of acetone were used as the starting materials, to give the title compound.

후처리

  1. customThe procedure described in Preparation 64

출처 및 근거

ORD 기록
ord-aca3391237b24c81b5b1d395ff756efc
출처 데이터셋
uspto-grants-1992_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05104888

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