HCID 3395423, 화합물 → 4-(1,3-Thiazol-4-yl)phenol

HRID 1030457노트

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HRID 1030457 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[CH:17][S:18][CH:19]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>Br>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[CH:17][S:18][CH:19]=2)=[CH:13][CH:14]=1

참가 물질

3

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HCID 3395423HCID 3395423, 화합물

생성물 1

HCID 98153854-(1,3-Thiazol-4-yl)phenol수율 63.9%

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

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온도
100 °C

실험 절차

To 4-(4-benzyloxyphenyl)thiazole (1.1 g) was added 47% aqueous hydrogen bromide (10ml), and the mixture was stirred at 100° C. for 30 minutes. Ice-water was added to the reaction mixture and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated saline, dried by anhydrous sodium sulfate and then concentrated. Crystals were collected by filtration by using hexane to give 4-(4-hydroxyphenyl) thiazole (466 mg, 63.8%). The crystals were purified by recrystallization from methylene chloride-hexane. m.p. 161.5°-162° C.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with saturated saline
  3. dry with materialdried by anhydrous sodium sulfate
  4. concentrationconcentrated
  5. filtrationCrystals were collected by filtration

출처 및 근거

ORD 기록
ord-202b7cb0ac41461ab7c4dd90063c88b6
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05106732

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