Sodium Hydroxide → 2-[2-(N-isobutyl-N-methylamino)benzylthio]imidazo[4,5-b]pyridine

HRID 1030803

반응식

HRID 1030803 반응식
[SH:1][C:2]1[NH:3][C:4]2[C:5]([N:10]=1)=[N:6][CH:7]=[CH:8][CH:9]=2.Cl.[CH2:12]([N:16]([C:18]1[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=1[CH2:20]Cl)[CH3:17])[CH:13]([CH3:15])[CH3:14].[OH-].[Na+]>C(O)C>[CH2:12]([N:16]([C:18]1[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=1[CH2:20][S:1][C:2]1[NH:3][C:4]2[C:5]([N:10]=1)=[N:6][CH:7]=[CH:8][CH:9]=2)[CH3:17])[CH:13]([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 148394442-(N-isobutyl-N-methylamino)benzyl chloride hydrochlorideHCID 178527819HCID 178527819, 화합물

생성물 1

HCID 148394452-[2-(N-isobutyl-N-methylamino)benzylthio]imidazo[4,5-b]pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Mercaptoimidazo[4,5-b]pyridine and 2-(N-isobutyl-N-methylamino)benzyl chloride hydrochloride were reacted in an aqueous ethanol solution in the presence of sodium hydroxide to obtain 2-[2-(N-isobutyl-N-methylamino)benzylthio]imidazo[4,5-b]pyridine in the same manner as in Example 1-(2). The obtained 2-[2-(N-isobutyl-N-methylamino)benzylthio]imidazo[4,5-b]pyridine was oxidized by m-chloroperbenzoic acid in chloroform in the same manner as in Example 9-(3) to give 2-[2-(N-isobutyl-N-methylamino)benzylsulfinyl]imidazo[4,5-b]pyridine as a pale yellow crystalline product. m.p.: 116°-118° C. (decompn.)

출처 및 근거

ORD 기록
ord-45001423ecf748c29b1065fea210f2ed
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05106976

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