홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

HCID 14460365, 화합물 → HCID 14460366, 화합물

HRID 1031046
노트
인쇄 미리보기

반응식

HRID 1031046 반응식
CC(C)([O-])C.[K+].[N:7]([CH2:10][C:11]([CH3:35])([CH3:34])[C:12](=[O:33])[CH:13]([N:27]1[CH:30](Cl)[CH2:29][C:28]1=[O:32])[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1)=[O:15])=[N+:8]=[N-:9]>C(O)(C)(C)C.O1CCCC1.C(OCC)(=O)C>[N:7]([CH2:10][C:11]([C:12]1[O:33][CH:30]2[N:27]([C:28](=[O:32])[CH2:29]2)[C:13]=1[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1)=[O:15])([CH3:35])[CH3:34])=[N+:8]=[N-:9]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 14460365HCID 14460365, 화합물HCID 23665647Potassium tert-butoxide

생성물 1

HCID 14460366HCID 14460366, 화합물수율 117.9%

시약·촉매·용매 3

HCID 6386tert-Butanol용매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate
용매

반응 조건

온도
-30 °C

실험 절차

313 μl of a 0.75 M solution of potassium tert-butoxide in tert-butanol are added at -30° C. to a solution of 107 mg (0.23 mmol) of p-nitrobenzyl 5-azido-2-(4-chloro-2-oxo-1-azetidinyl)-4,4-dimethyl-3-oxopentanoate in 4.5 ml of dry tetrahydrofuran and the solution is stirred at -30° C. during the course of 30 minutes. The reaction mixture is then diluted with 20 ml of ethyl acetate, and the mixture is washed with 10 ml of water and 10 ml of NaCl solution. The aqueous phases are extracted using 10 ml of ethyl acetate and the combined organic phases are dried over MgSO4, filtered and then evaporated in vacuo. In this way, 105 mg of a yellow residue are obtained which is crystallized from methylene chloride/ diisopropyl ether. Yield 61 mg of melting point 81°-82° C. IR spectrum in CH2 --Cl2 : 2950, 2860, 2110, 1810, 1720, 1590, 1530, 1370, 1320, 1085, 1020 cm-1.

후처리

  1. washthe mixture is washed with 10 ml of water and 10 ml of NaCl solution
  2. extractionThe aqueous phases are extracted
  3. dry with materialthe combined organic phases are dried over MgSO4
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-2a871b0d80c94ba781e6712e67b6391d
출처 데이터셋
uspto-grants-1992_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05108747

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트