Acetic Acid → HCID 19896855, 화합물

HRID 1031457노트

반응식

HRID 1031457 반응식
[CH3:1][C:2]1([CH3:23])[C:11]2[CH:10]=[C:9]3[NH:12][C:13]([C:15]4[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=4)=[N:14][C:8]3=[CH:7][C:6]=2[NH:5][C:4](=[O:22])[CH2:3]1.C(O)(=O)C.CO[CH:30]1[CH2:34][CH2:33][CH:32](OC)O1>Cl.O>[CH3:1][C:2]1([CH3:23])[C:11]2[CH:10]=[C:9]3[NH:12][C:13]([C:15]4[CH:20]=[CH:19][C:18]([N:21]5[CH:30]=[CH:34][CH:33]=[CH:32]5)=[CH:17][CH:16]=4)=[N:14][C:8]3=[CH:7][C:6]=2[NH:5][C:4](=[O:22])[CH2:3]1

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 790982,5-DimethoxytetrahydrofuranHCID 19896769HCID 19896769, 화합물

생성물 1

HCID 19896855HCID 19896855, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 962Water용매

실험 절차

3.06 g. 8,8-dimethyl-2-(4-aminophenyl)-5,6,7,8-tetrahydro-lH-imidazo[4,5-g]quinolin-6-one (see Example 38) were allowed to stand for 20 hours at 25° C. with 30 ml. glacial acetic acid, 5 ml. water, 2 drops of concentrated hydrochloric acid and 1.32 ml. 2,5-dimethoxytetrahydrofuran. The reaction mixture was then washed with 100 ml. water. After crystallisation from ethanol, there was obtained 0.8 g. of the title compound; m.p. 329 -350° C. (decomp.).

후처리

  1. washThe reaction mixture was then washed with 100 ml
  2. customAfter crystallisation from ethanol
  3. customthere was obtained 0.8 g

출처 및 근거

ORD 기록
ord-0398a2155117440493e50df7a67a2bcb
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954498

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