Sodium hydride → HCID 53937148, 화합물

HRID 1031506

반응식

HRID 1031506 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[C:6]([C:8]1[CH:9]=[CH:10][C:11]([N:14]([CH3:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:12][CH:13]=1)=O.C(OP([CH2:35][C:36]([N:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1)=[O:37])(OCC)=O)C.[H-].[Na+]>>[CH3:21][N:14]([C:11]1[CH:10]=[CH:9][C:8]([C:6]([C:5]2[CH:22]=[CH:23][C:24]([O:25][CH3:26])=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:35][C:36]([N:38]2[CH2:43][CH2:42][O:41][CH2:40][CH2:39]2)=[O:37])=[CH:13][N:12]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 11207805Phosphonic acid, [2-(4-morpholinyl)-2-oxoethyl]-, diethyl esterHCID 14878865HCID 14878865, 화합물

생성물 1

HCID 53937148HCID 53937148, 화합물수율 32.1%

실험 절차

In the same manner as in Example 1, using 5-(3,4-dimethoxybenzoyl)-2-(N-methylanilino)pyridine (500 mg), diethylphosphonoacetic acid morpholide (800 mg) and 60% sodium hydride (150 mg), E-isomer (250 mg) and Z-isomer (212 mg) of 4-[3-(2-(N-methylanilino)-5-pyridyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine (Compound No.62) were obtained.

출처 및 근거

ORD 기록
ord-60040d8caa1041c58f900df3b01c3d8d
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954497

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