Acetic Anhydride → 3-Acetylamino-4-phenoxyphenol

HRID 1031652노트

반응식

HRID 1031652 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([OH:15])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(O)(=O)C>[C:16]([NH:1][C:2]1[CH:3]=[C:4]([OH:15])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:18])[CH3:17]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 135148453-Amino-4-phenoxyphenol

생성물 1

HCID 147222783-Acetylamino-4-phenoxyphenol수율 93%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

20.1 g of 3-amino-4-phenoxyphenol was dissolved in 60 ml of acetic acid. 30 ml of acetic anhydride was added thereto with ice cooling. Stirring was conducted at 20°-25° C. for 1 hour. The mixture was subjected to distillation under reduced pressure to remove the solvent. The resulting crystal was recrystallized from toluene to obtain 22.6 g (yield: 93%) of 3-acetylamino-4-phenoxyphenol having a melting point of 151°-153° C.

후처리

  1. distillationThe mixture was subjected to distillation under reduced pressure
  2. customto remove the solvent
  3. customThe resulting crystal was recrystallized from toluene

출처 및 근거

ORD 기록
ord-0c9dfc0593534a4a8f3792e3327779f7
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954518

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