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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

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Water → 2-amino-3-carbamoyl-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

HRID 1031740

인쇄 미리보기

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HRID 1031740 반응식

[C:1]([C:3]1[C:8](=[O:9])[C:7]2[CH:10]=[C:11]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:12]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:13][C:6]=2OC=1)#[N:2].Cl.N[OH:28].O.C[N:31](C)[CH:32]=[O:33]>C(O)C>[NH2:31][C:32]1[O:33][C:6]2[CH:13]=[C:12]([NH:14][S:15]([CH3:18])(=[O:16])=[O:17])[C:11]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:10][C:7]=2[C:8](=[O:9])[C:3]=1[C:1](=[O:28])[NH2:2]

참가 물질 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

6

반응물 4

HCID 6228Dimethylformamide

HCID 443297Hydroxyamine hydrochloride

HCID 147224153-cyano-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

생성물 1

HCID 147224242-amino-3-carbamoyl-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one수율 72%

시약·촉매·용매 1

HCID 702

Ethanol

용매

실험 절차

3.56 g of 3-cyano-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one, 970 mg of hydroxylamine hydrochloride, 1.5 ml of water, 7 ml of N,N-dimethylformamide and 150 ml of ethanol were mixed, and subjected to refluxing for 3 hours. The reaction mixture was cooled, and thereafter, the precipitated crystals were collected by filtration and then recrystallized from acetonitrile to obtain 2.8 g (yield: 72%) of 2-amino-3-carbamoyl-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one having a melting point of >250° C.

후처리

temperatureto refluxing for 3 hours
temperatureThe reaction mixture was cooled
filtrationthe precipitated crystals were collected by filtration
customrecrystallized from acetonitrile

출처 및 근거

ORD 기록: ord-5a7fca6c37fb496e93e1186aa3525605
출처 데이터셋: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04954518

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